期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 72, 期 3, 页码 626-629出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2009.03.007
关键词
Nanotoxicology; Silica particle; Histological analysis; Liver; Spleen
资金
- Ministry of Health, Labor, and Welfare of Japan
Nano-sized silica is a promising material for disease diagnosis, cosmetics and drugs. For the successful application of nano-sized material in bioscience, evaluation of nano-sized material toxicity is important. We previously found that nano-sized silica particles with a diameter of 70 am showed acute liver failure in mice. Here, we performed histological analysis of major organs Such as the liver, spleen, lung, kidney, brain and heart in mice. chronically injected with 70-nm silica particles for 4 weeks. Histological analysis revealed hepatic microgranulation and splenic megakaryocyte accumulation in these 70-nm silica particles treated mice, while the kidney, lung, brain and heart remained unaffected. Thus, liver and spleen appear to be the major target organs for toxicity by the chronic administration of the 70-nm silica particles. (C) 2009 Elsevier B.V. All rights reserved.
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