Nanoparticles for drug delivery: The need for precision in reporting particle size parameters

Polymeric drug-loaded nanoparticles have been extensively studied in the field of drug delivery. Biodistribution depends on the physicochemical properties of particles, especially size. The global message from the literature is that small particles have an enhanced ability to reach their target. The present review highlights the difficulties in validating the data from biodistribution studies without accurate particle size determination. (C) 2007 Elsevier B.V. All rights reserved.