期刊
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 48, 期 3, 页码 416-427出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejps.2012.12.006
关键词
Nanoparticles; Chemotherapy; Cancer; Liposomes; Micelles; Nanosphere
资金
- National Institutes of Health NCI Center for Oncophysics [CTO PSOC U54-CA-143837]
- National Institutes of Health [EB-00246-18]
The tumor microenvironment provides unique challenges for the delivery of chemotherapeutic agents in doses that are effective while ensuring minimal systemic toxicity. The primary limitation of current therapeutics is a lack of specificity in delivery, as they target healthy and cancerous cells alike. The development of nanoscale carriers capable of delivering cancer therapies has the potential to overcome both systemic and tumor barriers and provide specific, targeted delivery. This review seeks to provide an overview of available nanoscale drug carriers by exploring the wide variety of developed nanostructures and the most commonly used moieties for targeted delivery. Additionally, the use of nanoscale carriers will be motivated by examining tumor physiology and the specific barriers present within both the tumor microenvironment and systemic delivery. (C) 2012 Elsevier B.V. All rights reserved.
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