期刊
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 47, 期 5, 页码 926-933出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejps.2012.09.013
关键词
N-terminal fragment analog of hPTH; Osteoporosis; Biomechanic property; Histomorphologic property; Anti-fracture capability
资金
- National Natural Science of China [30270298]
- National High Technology 863 Programs of China [2002 AA217031-2]
- Leading Academic Discipline Project of Shanghai Municipal Education Commission [J50704]
- SHOU Project [05-207]
Osteoporosis is a skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, and it is a serious threat to human lives. We previously showed that the N-terminal peptide analog of human parathyroid hormone (Pro-Pro-PTH(1-34)) enhanced plasma calcium concentration. In this paper, we study the impact of PTH N-terminal fragment analog on the structure, component, and mechanical properties of the rat bones. Daily subcutaneous injections of Fro-Pro-hPTH (1-34) induces 26.5-32.8% increase in femur bone mineral density (BMD), 23.0-34.2% decrease the marrow cavity or increase in trabecular bone area. The peptide also increases 16.0-59.5%, 28.8-48.2% and 14.0-17.8% of bone components of calcium, phosphorus and collagen, respectively. In terms of mechanic properties, administration of the peptide elevates the bone rigidity by 45.4-76.6%, decreases the flexibility by 23.0-31.6%, and improves modulus of elasticity by 32.8-63.4%. The results suggest that Pro-Pro-hPTH (1-34) has a positive effect on bone growth and strength, and possesses anti-fracture capability, thus a potential candidate for the application for the treatment of osteoporosis. (C) 2012 Elsevier B.V. All rights reserved.
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