期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 73, 期 5, 页码 S66-S69出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2015.07.040
关键词
acne fulminans; antibiotic therapy; hidradenitis suppurativa; microbiome host disease; PASH syndrome; pyoderma gangrenosum; remission; severe acne
类别
资金
- AbbVie Corporation
- Fondation pour la Recherche Medicale (ROXANNE project) [LMV20100519581]
Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance therapy is also necessary to prevent disease relapse. The response to antibiotic therapy is hypothesis generating, raising the issue of a modified host response. To date, anecdotal reports support the use of surgery and medical therapy, but controlled investigations with extended follow-up are necessary to substantiate preliminary data observed with individual cases.
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