期刊
EUROPEAN JOURNAL OF PAIN
卷 16, 期 9, 页码 1232-1242出版社
WILEY
DOI: 10.1002/j.1532-2149.2012.00131.x
关键词
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资金
- Australian National Health and Medical Research Council [323200, 403981, 572613, 425513, 373638, 353514]
- Raine Medical Research Foundation
- University of Western Australia
- Curtin University
- Faculty of Medicine, Dentistry and Health Sciences at the University of Western Australia
- Women and Infants Research Foundation
- Telethon Institute for Child Health Research
Background There is significant evidence to suggest that psychological and stress-related factors are important predictors of the onset of chronic widespread pain (CWP) and fibromyalgia (FM). The hypothalamic-pituitary-adrenal axis, together with the efferent sympathetic/adrenomedullary system, influence all body organs (including muscles) during short- and long-term threatening stimuli. The aim of this study was to investigate the relationship between genetic variants in adrenergic candidate genes and chronic musculoskeletal complaints (MSCs) in adolescents. Methods Adolescents from the Western Australian Pregnancy (Raine) Cohort attending the 17-year cohort review completed a questionnaire containing a broad range of psychosocial factors and pain assessment (n?=?1004). Blood samples were collected for DNA extraction and genotyping. Genotype data was obtained for 14 single nucleotide polymorphisms (SNPs) in two candidate genes beta-2 adrenergic receptor (ADRB2) and catecholamine-O-methyltransferase (COMT). Haplotypes were reconstructed for all individuals with genotype data. Results and Conclusion Both female gender and poor mental health were associated with (1) an increased risk for chronic, disabling comorbid neck and low back pain (CDCP); and (2) an increase in the number of areas of pain. Of the 14 SNPs evaluated, only SNP rs2053044 (ADRB2, recessive model) displayed an association with CDCP [odds ratio (OR)?=?2.49; 95% confidence interval (CI)?=?1.25, 4.98; p?=?0.01] and pain in three to four pain areas in the last month (OR?=?1.86; 95% CI?=?1.13, 3.06; p?=?0.02). These data suggest that genetic variants in ADRB2 may be involved in chronic MSCs.
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