期刊
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
卷 15, 期 1, 页码 8-14出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejpn.2010.09.003
关键词
Dravet syndrome; Drug-resistant epilepsy; VNS; Efficacy
Medical treatment of Dravet syndrome is disappointing. Ketogenic Diet and neuro-stimulation procedures as Vagus Nerve Stimulation (VNS) and Deep Brain Stimulation are in ongoing evaluation. In the present study, the long-term effectiveness of VNS on seizures, cognition and behavior was retrospectively evaluated in eight young patients with DS and medically refractory epilepsy (mean age at VNS implant: 10.28 years, range: 5-25). The average duration of treatment was 54 months (range: 12-120). Compared to baseline (mean: 55; standard deviation: 83, range: 4-200), the mean number of monthly seizures after VNS implantation was 39 +/- 67 at 3 months, 42 +/- 67 at 6 months and 38 +/- 69 at twelve months (not significant comparisons). In particular, VNS produced a mean seizure rate reduction of 12% at three months, 6% at six months, and 31% at twelve months. All patients but three experienced some reduction in seizure burden (range: 33-61%) at twelve months. Seizure outcome after one year of stimulation was rated as Mc Hugh class II (50-79% reduction in seizure frequency) in four patients, class III (<50% reduction) in one patient and class V (no improvement) in three patients. In this small case series of patients with DS, VNS therapy had a clinically significant effect in reducing seizures at twelve months in four of the eight patients. Even in patients in whom seizure reduction was not dramatic, a slight improvement in alertness and communicative skills was seen. The long-term clinical course of two selected cases is discussed. (C) 2010 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
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