期刊
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
卷 15, 期 6, 页码 478-486出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejpn.2011.04.007
关键词
Developmental pharmacology; Pharmacokinetics; Pharmacodynamics; Neonate; Antidepressants; Analgosedatives
资金
- Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen) [1800209N]
The principles of clinical pharmacology also apply to neonates, but their characteristics warrant a tailored approach. We focus on aspects of both developmental pharmacokinetics (concentration/time relationship) and developmental pharmacodynamics (concentration/effect relationship) in neonates. We hereby aimed to link concepts used in clinical pharmacology with compound-specific observations (anti-epileptics, analgosedatives) in the field of neonatal neurology. Although in part anecdotal, we subsequently illustrate the relevance of developmental pharmacology in the field of neonatal neurology by a specific intervention (e.g. whole body cooling), specific clinical presentations (e.g. short and long term outcome following fetal exposure to antidepressive agents, the development of new biomarkers for fetal alcohol syndrome) and specific clinical needs (e.g. analgosedation in neonates, excitocytosis versus neuro-apoptosis/impaired synaptogenesis). (C) 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
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