期刊
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
卷 13, 期 5, 页码 397-407出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejpn.2008.09.001
关键词
Cerebellar disruption; Cerebellar hypoplasia; Unilateral cerebellar hypoplasia; Cerebellar agenesis; Vanishing cerebellum; Neuroimaging
资金
- United Bank of Switzerland (UBS)
There is increasing evidence that the cerebellum is susceptible to both prenatal infections and haemorrhages as well as being vulnerable in extremely preterm babies, but not to perinatal and postnatal hypoxic-ischaemic injuries. Starting with the imaging appearance we describe and illustrate a spectrum of prenatal cerebellar disruptions: cerebellar agenesis; unilateral cerebellar hypoplasia; unilateral cerebellar cleft; global cerebellar hypoplasia; vanishing cerebellum in myelomeningocele; and disruption of cerebellar development in preterm infants. We discuss neuroradiological characteristics, possible disruptive events, and clinical findings in the different morphological patterns. Remarkably, the same disruptive agent can cause different neuroradiological patterns, which appear likely to represent a morphological spectrum. The analysis of imaging patterns is crucial in recognising cerebellar disruptions. Recognition of cerebellar disruptions and their differentiation from cerebellar malformations is important in terms of diagnosis, prognosis, and genetic counselling. (C) 2008 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
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