期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2018, 期 46, 页码 6486-6493出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201801134
关键词
2-Pyridone; 2-Hydroxypyrimidine; Deteurated amino acids; beta-Amino acids; delta-Amino acids
A practical and efficient two-step procedure is reported for the preparation of a variety of alpha-, beta-, gamma- and delta-amino acids from 2-pyridone, 2-pyrazinone or 2-hydroxypyrimidine and derivatives. The procedure is amenable to scale-up and in most cases no chromatographic purification of the product is required. This approach is useful, especially in the synthesis of amino acids or deuterated amino acids that are not obtained by other methods.
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