Direct Trifluoromethylthiolation Reactions: The Renaissance of an Old Concept

Because of its high lipophilicity, the CF3S group has always interested chemists. However, strategies to introduce it into organic molecules have been, for the most part, reserved to specialized fluorine chemists. Recent published work has demystified these preconceived ideas by proposing new efficient methods or easy-to-handle reagents to enrich the toolbox of chemists. However, all these new concepts arise from the pioneering works of the past! In this review, we will do a back to the future by remembering the most significant results of the past and by presenting extensions and novelties of the present and for the future.