A Route for the Total Synthesis of Enantiomerically Enriched Jasmonates 12-COOH-JA and 12-COOH-JA-Ile

Enantiomerically enriched oxidized conjugated or non-conjugated jasmonate derivatives were obtained through 3-alkynoates. Stereoselective reduction of the triple bond afforded exclusively the Z isomer. Protection of the amide function led to the non-conjugated derivatives, whereas the free amides provided the oxidized isoleucine derivatives of jasmonate.