Asymmetric Synthesis of 2-Heteroaryl Cyclic Amines: Total Synthesis of (-)-Anabasine

A new and concise method for the synthesis of enantioenriched 2-heteroaryl cyclic amines was developed through an intramolecular chirality transfer. The influence of the nature of both ring size and heteroaryl moiety was investigated. The versatility of this reaction was demonstrated by the enantioselective synthesis of (-)-anabasine.