Metal-Free Oxidative Carbon-Heteroatom Bond Formation Through C-H Bond Functionalization

Direct methods of carbon-heteroatom bond formation through functionalization of non-reactive C-H bonds represent an attractive approach to the synthesis of interesting products. This review focuses on the development of metal-free coupling methods for unactivated compounds under oxidative reaction conditions. The utility of these methods in syntheses of desired products and the mechanisms of their formation are discussed with numerous examples.