4.5 Article

A Metal-Free Route to CF3-Containing Oxindoles by PhI(OAc)2-Mediated Trifluoromethylation of N-Arylacrylamides with TMSCF3

期刊

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2014, 期 4, 页码 709-712

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201301512

关键词

Synthetic methods; Amides; Fluorine; Iodine; Heterocycles

资金

  1. National Natural Science Foundation of China (NSFC) [U1204205, 21202078, 21272110]

向作者/读者索取更多资源

A mild and efficient PhI(OAc)(2)-mediated trifluoromethylation reaction of N-arylacrylamides with TMSCF3 under metal-free conditions was developed. This method provides convenient access to a variety of useful CF3-containing oxindoles in moderate to good yields.

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