Organocatalytic Synthesis of (Arylselanyl)phenyl-1H-1,2,3-triazole4-carboxamides by Cycloaddition between Azidophenyl Arylselenides and β-Oxo-amides

We describe the use of -oxo-amides in organocatalytic cycloaddition with aryl azidophenyl selenides. The cycloaddition reactions were performed under mild conditions, with -oxo-amides and aryl azidophenyl selenides in the presence of a catalytic amount of Et2NH (5 mol-%), and the corresponding products were obtained in good to excellent yields. This organocatalytic methodology tolerated a range of substituents either in the -oxo-amides or in the aryl azidophenyl selenides and proved to be an efficient methodology for the combinatorial synthesis of new selenium-containing triazole compounds.