期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2013, 期 24, 页码 5445-5454出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201300642
关键词
Synthetic methods; Reductive alkylation; Palladium; Hydrogenation; Ureas
Palladium-catalysed reductive alkylation of monosubstituted ureas has been studied in the presence of aldehydes and using molecular hydrogen as a clean reductant. Unsymmetrical N,N-disubstituted ureas were formed in good to excellent isolated yields (60-93%) without the production of salt waste. This reaction was incorporated to a one-pot, solvent-free sequence involving the alkylation of monosubstituted ureas generated in situ from the corresponding amines.
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