4.5 Article

Stereoselective Total Synthesis of Attenols A and B

期刊

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2013, 期 28, 页码 6317-6324

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201300623

关键词

Natural products; Spiro compounds; Cyclization; Total synthesis

资金

  1. Council of Scientific and Industrial Research (CSIR)
  2. University Grants Commission (UGC), New Delhi, India

向作者/读者索取更多资源

A highly stereoselective total synthesis of attenols A and B is described. The salient features of this synthesis are the utilization of a reductive radical cyclization strategy for methyl center creation, a Prins cyclization/reductive opening cascade for anti-1,3-diol motif generation, and a double alkylation tosylmethyl isocyanide (TosMIC) strategy to construct the spiro acetal segment.

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