4.5 Article

An Efficient Formal Total Synthesis of Cladosporin

期刊

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2013, 期 14, 页码 2859-2863

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201300053

关键词

Total synthesis; Natural products; Oxygen heterocycles; Metathesis

资金

  1. Council of Scientific and Industrial Research (CSIR), New Delhi
  2. CSIR

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A highly diasteroselective and efficient approach for the formal total synthesis of cladosporin is described. Cross-metathesis, iodocyclization to construct the trans-2,6-disubstituted dihydropyran ring system, and an AlderRickert reaction to form the aromatic ring were used as the key steps.

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