Copper-Catalyzed Oxidative Coupling of Carboxylic Acids with N,N-Dialkylformamides: An Approach to the Synthesis of Amides

A new synthetic approach for amide bond formation through the oxidative coupling of N,N-dialkylformamides with carboxylic acids was achieved by using a copper catalyst. Furthermore, this method was applied in the coupling of chiral amino acids in which the stereochemistry was retained in the resulting amide products.