期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2013, 期 19, 页码 4131-4145出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201300246
关键词
Nitrogen heterocycles; Multicomponent reactions; Michael addition; Reaction mechanisms; Heterogeneous catalysis
资金
- Aix-Marseille Universite
- Centre National de la Recherche Scientifique (CNRS) (iSm2 UMR 7313 and RDR2 research network)
- French Research Ministry
- Centre National de la Recherche Scientifique (CNRS)
- Conseil Regional PACA
A metal-free and completely regioselective three-component synthesis of highly functionalized pyridines from 1,3-dicarbonyl derivatives and Michael acceptors has been achieved. Activated Michael acceptors, that is, ,-unsaturated -oxo carbonyl derivatives, were utilized, allowing substitution at the 4-position and remarkable functional diversity at the 2-position of the pyridine ring. The scope and limitations of this environmentally friendly domino reaction are disclosed, with full experimental data, and the results of mechanistic investigations are discussed.
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