期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2012, 期 13, 页码 2516-2519出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201200053
关键词
Structure elucidation; Natural products; Cytotoxicity; Configuration determination
资金
- National Natural Science Foundation of China [31000011]
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines
- Chinese National S&T Special Project on Major New Drug Innovation [2011ZX09307-002-01, 2012ZX09301002-001]
Two new cytochalasans, trichoderones A (1) and B (2), and three known analogues, aspochalasins D (3), J (4), and I (5), were isolated from the endophytic fungus Trichoderma gamsii. Their structures were determined by analysis of their spectroscopic data. The absolute configurations of 1 and 2 were established by quantum chemical electronic circular dichroism calculations. Compounds 3 and 4 displayed cytotoxic activity against the HeLa cell line. Trichoderone A (1) possesses an unprecedented 7/6/6/5/5 pentacyclic system, whereas trichoderone B (2) contains the rare 6/5/6/6/5 pentacyclic skeleton with a 12-oxatricyclo [6.3.1.02,7] moiety.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据