期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2013, 期 5, 页码 894-906出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201201220
关键词
Natural products; Alkaloids; Circular dichroism; Configuration determination; Structure elucidation; Density functional calculations
资金
- German Bundesministerium fur Bildung und Forschung (BMBF)
- Ministry of Science and Technology of China (MOST)
- China Scholarship Council
- Ministry of Education of China for a scholarship
- European Union (EU)
- European Regional Development Fund [HURO/0901/274/2.2.2]
- National Information Infrastructure Development Institute [NIIFI 10038]
Seven new alkaloids including tryptoquivaline K (1) and fumiquinazolines K-P (2-7), bearing a rare 1-aminocyclopropane- 1-carboxylic acid residue, together with six known compounds (8-13), were isolated from the fungus Aspergillus sp. obtained from the Mediterranean sponge Tethya aurantium. The structures of the new compounds were determined by extensive analysis by 1D and 2D NMR spectroscopy and mass spectrometry. The absolute configurations of tryptoquivaline K (1) and fumiquinazolines K and L (2, 3) were determined by TDDFT ECD calculations of their solution conformers, and the configurational assignment of the related fu-miquinazolines M-P (4-7) was achieved by comparison of their ECD spectra with those of compounds 2 and 3. All compounds were evaluated for their cytotoxic activity by the MTT method. Compound 8 exhibited pronounced cytotoxicity against the mouse lymphoma cell line (L5178Y) with an IC50 value of 3.6 M, but only moderate activity was observed against human ovarian cancer (A2780) and human Philadelphia chromosome-positive chronic myelogenous leukemia (K562) cell lines with IC50 values of 18.5 and 15.0 mu M, respectively.
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