期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2012, 期 16, 页码 3059-3067出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201101840
关键词
Enzyme catalysis; Biocatalysis; C-C coupling; Nitroaldol reaction; Nitro alcohols
资金
- Food's Food Institutional Research Measure (FIRM) [08/RD/AFRC/673]
- Irish Research Council for Science, Engineering & Technology (IRCSET)
- Pfizer Pharmaceuticals
- European Regional Development Fund under the European Sustainable Competitiveness Program for Northern Ireland
Enantiopure beta-nitro alcohols are key chiral building blocks for the synthesis of bioactive pharmaceutical ingredients. The preparation of these target compounds in optically pure form has been the focus of much research and there has been an emergence of biocatalytic protocols in the past decade. For the first time, these biotransformations are the focus of this review. Herein, we describe two principal biocatalytic approaches to the Henry (nitroaldol) reaction. The first method is a direct enzyme-catalysed carboncarbon bond formation resulting in either an enantio-enriched or enantiopure beta-nitro alcohol. The second approach describes the Henry reaction without stereocontrol followed by a biocatalytic resolution to yield the enantiopure beta-nitro alcohol.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据