期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2012, 期 11, 页码 2095-2108出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201101609
关键词
Natural products; Total synthesis; Biosynthesis; Carbohydrates; Carbasugars; Structure-activity relationships; Jadomycin; Digitoxose
资金
- National Institutes of Health (NIH) [GM090259 and GM088839]
- National Science Foundation (NSF) [CHE-0749451]
- Department of Chemistry and Chemical Biology at Northeastern University
Jadomycins are unique angucycline polyketides produced by Streptomyces venezuelae soil bacteria under specific nutrient and environmental conditions. Their unique structural complexity and biological activities have engendered extensive study of the jadomycin class of natural compounds in terms of biological activity, biosynthesis, and synthesis. This review outlines recent developments in the study of the synthesis and biosynthesis of jadomycins.
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