An Efficient Class of P,N-Type PhMezole-phos Ligands: Applications in Palladium-Catalyzed Suzuki Coupling of Aryl Chlorides

This study describes an efficient class of hemilabile benzimidazolylphosphane ligands that can be easily accessed from commercially available and inexpensive starting materials. The application of this ligand array in the palladium-catalyzed SuzukiMiyaura coupling reaction of aryl chlorides with arylboronic acids is described. The palladium catalyst generated from this hemilabile phosphane is highly effective in the SuzukiMiyaura coupling of unactivated aryl chlorides, and catalyst loadings as low as 1 ppm can be achieved.