期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2013, 期 4, 页码 693-700出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201201150
关键词
Synthetic methods; Nitrogen heterocycles; Iodine; Oxidation; Cyclization; Cross-coupling; Alkynes
资金
- Fund for Scientific Research, Flanders, Belgium (FWO)
- Research Fund of the University of Leuven (KU Leuven)
- Erasmus Mundus External Cooperation Window (EMECW)
A mild and efficient iodine-mediated intramolecular heteroannulation approach for the construction of the imidazo[1,2-a]pyrazinone core has been developed. Under ambient conditions, this metal-free protocol allows easy access to densely functionalized imidazo[1,2-a]pyrazinone-3-carbaldehydes or (aminomethyl)imidazo[1,2-a]pyrazinones from substrates containing terminal alkynes by cyclization and subsequent oxidation or amination. Further diversification may be introduced by using substrates containing an internal alkyne and/or Suzuki coupling after cyclization to generate polysubstituted (dihydro)imidazo[1,2-a]pyrazinones.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据