期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2012, 期 13, 页码 2635-2642出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201200092
关键词
Synthetic methods; Homogeneous catalysis; Organocatalysis; Palladium; Aldol reactions
资金
- University of Palermo
- Italian Ministero dell'Universita e della Ricerca (MIUR)
Here we describe for the first time a sequential Suzuki/asymmetric aldol reaction. Such sequential approach was achieved through the combined use of an ionic liquid supported palladium catalyst and the organocatalyst trans-4-(2,2-diphenylacetoxy)proline. Suzuki and asymmetric aldol reactions were performed under aqueous conditions. The use of a palladium catalyst under basic conditions allowed also the first example of sequential Suzuki/Knoevenagel reaction. Reactions were carried out under aqueous conditions and products were isolated in good to high yields and, in the case of the Suzuki/aldol reaction, with diastereoselectivities up to 91:9 and enantioselectivities up to at least 99?%.
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