New Linearly and Angularly Fused Quinazolinones: Synthesis through Gold(I)-Catalyzed Cascade Reactions and Anticancer Activities

A robust library-based approach to new fused quinazolinones by the development of gold(I)-catalyzed cascade reactions between 2-aminobenzohydrazides and alkynoic acids is documented. Selected compounds were administered to lung (A549) and breast cancer cells (MDA-MB-231 and MCF-7) in vitro and it was found that some successfully inhibited cell proliferation.