期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2011, 期 12, 页码 2319-2325出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201001618
关键词
Medicinal chemistry; Nitrogen heterocycles; Synthesis design; Antipsychotics; Hydroxylation; Oxidation
资金
- Fondazione San Paolo
A very short and cost-effective synthesis of the commercial drug paliperidone has been achieved starting from its parent compound risperidone, through a thoroughly optimized oxidation with air under basic conditions.
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