期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2011, 期 24, 页码 4532-4535出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201100680
关键词
Alkaloids; Arylation; Boron; C-C coupling; Multicomponent reactions; Palladium
资金
- Merck KGaA
- Darmstadt
- Fonds der Chemischen Industrie
Diazine-bridged bisindoles are readily obtained from N-Boc-protected 3-iodoindoles and 3-iodo-7-azaindole in a pseudo three-component reaction involving a one-pot Masuda borylation-Suzuki arylation sequence. Some of the title compounds display promising cytotoxic properties. The versatility of this methodology is illustrated by a very concise total synthesis of the marine alkaloid hyrtinadine A.
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