Organocatalyzed Enantioselective Synthesis of Quaternary Carbon-Containing Isoindolin-1-ones

3,3'-Triphenylsilyl-substituted (S)-BINOL-based (1,1'-bi-2-naphthol) phosphoric acid has proven to be an effective organocatalyst for the asymmetric Friedel-Crafts alkylation of indoles with 3-substituted 3-hydroxyisoindolin-1-ones, affording the corresponding quaternary carbon-containing 3,3-disubstituted isoindolin-1-ones in good yields (up to 99%) with good to excellent enantioselectivities (up to 95% ee). The optical purity of the product was further improved after a single recrystallization. This protocol provides a convenient method for the catalytic asymmetric synthesis of valuable 3,3-disubstituted isoindolin-1-ones in high yields and enantioselectivities.