期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2011, 期 23, 页码 4327-4334出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201100310
关键词
Oxidation; Titanium; Reaction mechanisms; Enantioselectivity; Circular dichroism
资金
- Ministero dell'Universita e della Ricerca (MIUR), Rome
- University of Bari
A series of experiments was performed to test a theoretical model that we have recently proposed to explain the highly enantioselective oxidation of aryl benzyl sulfides with tertbutyl hydroperoxide in the presence of a complex between titanium and (S,S)- or (R,R)-hydrobenzoin. The studied variations involved the sulfides, the ligands, and the order of addition of reactants. The reaction path predicted by our model was confirmed in every experiment. In particular, aryl benzyl sulfides behaved as the ideal substrate for this type of asymmetric oxidation, which yields synthetically useful, enantio-pure aryl benzyl sulfoxides in a straightforward manner.
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