Highly Enantioselective Direct Michael Addition of 1H-Benzotriazole to Chalcones Catalyzed by Sc(OTf)3/N,N′-Dioxide Complex

The N,N'-dioxide-Sc(OTf)(3) complex was applied in the asymmetric Michael reaction of 1H-benzotriazole with chalcones to give the corresponding N-1 products in excellent yields (up to 99%) with excellent enantioselectivities (up to 99% ee). Further transformation into other optically active derivatives such as beta-benzotriazolyl ester, alcohol, and amide were also realized with excellent results.