期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2011, 期 15, 页码 2845-2853出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201100131
关键词
Natural products; Total synthesis; Cycloaddition; Regioselectivity; Nitrogen heterocycles
The total synthesis of the bacterial-derived, pentacyclic, antitumor antibiotic lavendamycin has been achieved through a highly convergent strategy. The key step of this synthesis is a ruthenium-catalyzed [2+2+2] cycloaddition of an electron-deficient nitrile to an alkynyl-ynamide to prepare the carboline scaffold. The elaborate cycloaddition substrate is obtained in few steps by an N-ethynylation using alkynyliodonium salt chemistry and two palladium-catalyzed cross-coupling reactions. An efficient synthesis of a halogenated quinoline-5,8-dione building block starting from hydroquinone is presented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据