期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2011, 期 35, 页码 7148-7154出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201101094
关键词
Medicinal chemistry; Synthetic methods; Carboxylic acids; Boranes; Phosphorus; Arbuzov reaction
资金
- OSEO-Anvar Agency
- Ministere de l'Enseignement Superieur et de la Recherche
By starting with various carboxylic acids, a one-pot procedure for the synthesis of the corresponding 1-hydroxy-1,1-bis(phosphonic acid)s is reported. The efficiency of this simple methodology is illustrated by synthesizing well-known marketable amino hydroxy bis(phosphonate)s such as alendronate or N-methyl pamidronate without additional steps for the protection/deprotection of the amine function.
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