期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2011, 期 16, 页码 3050-3059出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201100155
关键词
Natural products; Antitumor agents; Synthesis design; Myxobacteria; Tubulysins
资金
- Deutsche Forschungsgemeinschaft (DFG) [FOR 1406, Ka 880/10-1]
The syntheses of new tubulysin analogues are described, in which the central amino acid, tubuvaline, is replaced by the rather simple building blocks phenyltubuvaline and phenoxytubuvaline. These analogues can be obtained in only two to three steps from easily accessible starting materials. Although the new derivatives are less active than the tubulysins, their activities towards U-2 OS tumor cells are still in the nanomolar range.
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