期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2011, 期 31, 页码 6294-6303出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201100900
关键词
Lipids; Fluorophore; Click chemistry; Fluorescence; Phosphoramidates
资金
- Association Francaise contre les Myopathies (Evry, France)
- Conseil Regional de Bretagne
- Brest Metropole Oceane
- Service Commun RMN-RPE UBO et spectrometrie de masse
The synthesis of fluorescent lipophosphoramidates is reported. Their modular construction allows several variations of the molecular structure including the separation of the fluorescent probe from the lipophosphoramidate moiety by a short methylene or by a tetraethylene glycol spacer. The last step of the convergent synthesis is a Huisgen click reaction, which assembles the fluorescent probe with the lipophosphoramidate part. Five fluorescent probes have been considered in this study including coumarin, NBD, fluorescein, naphthalimide and cyanine.
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