期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2010, 期 7, 页码 1284-1289出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200901126
关键词
Antibiotics; Structure elucidation; Molecular modeling; Natural products
资金
- Fonds der Chemischen Industrie
The macrolide ketocarbonic acid carolacton (1) was isolated from the myxobacterium Sorangium cellulosum, strain So ce960, because of its antibiotic activity. Subsequently, carolacton (1) was discovered to be a highly potent agent against biofilms containing the caries- and endocarditis-associated bacterium Streptococcus mutans. The 2D structure of I was elucidated by FIRMS, IR and 2D NMR spectroscopy. Initially, the stereogenic centres were determined by chemical derivatization in combination with computional methods and finally verified by X-ray analysis.
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