期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2010, 期 33, 页码 6338-6347出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000802
关键词
Alkynes; Copper; Click chemistry; Multicomponent reactions; Regioselectivity; Zeolites
资金
- Centre National de la Recherche Scientifique (CNRS)
- French Ministry of Research
- Loker Institute, Los Angeles
- French Embassy in New Delhi, India
Copper(I)-modified zeolites, especially Cu-I-USY, proved to be very efficient catalysts in multi-component reactions of epoxides with sodium azide and terminal alkynes. Such catalysts allow highly regio- and stereoselective syntheses of hydroxymethylated triazoles. These heterogeneous, modified zeolites can easily be recovered and reused. Moreover, the cascade reaction was best performed in water at room temperature, rendering all the processes truly green. Detailed investigations revealed the role the Cu-I-modified zeolites play both during the epoxide ring-opening and cycloaddition steps.
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