期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2010, 期 17, 页码 3229-3236出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000125
关键词
Nucleosides; Olieonucleotides; DNA; Phosphanes; Palladium
资金
- European Union [MEXT-2004-014320]
- Wellcome Trust
Seven phosphane-functionalized deoxyuridines have been prepared by amide bond formation between aminodeoxyuridines and phosphanylcarboxylic acids. X-ray crystal structures for two of these new modified nucleosides have been obtained. The same coupling method has been extended to oligonucleotides. The phosphane containing strands have been purified and characterized by MALDI-TOF and, for the first time, P-31 NMR spectrometry. Coordination of a phosphane-modified 15-mer to a [PdCl(eta(3)-allyl)] moiety has been confirmed by P-31 NMR spectroscopy.
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