Practical Synthetic Approach to Chiral Sulfonimides (CSIs) - Chiral Bronsted Acids for Organocatalysis

A general approach to the synthesis of optically pure 3,3'-diaryl chiral sulfonimides (CSIs) from racemic BINOL has been developed ortho-Lithiation is directed by the sulfonyl groups, and the resulting dihalides serve as the common precursors for the aryl-substituted CSIs.