Sequential Sonogashira/Carbopalladative Cyclization/Suzuki Reactions Catalyzed by a Single Palladium Source by Using Protected Homopropargyl Alcohol

A novel cascade combination reaction catalyzed by a single palladium source for the synthesis of various indene derivatives is reported. The approach involved sequential Sonogashira/carbopalladative cyclization/Suzuki coupling reactions by using three readily available components, such as homopropargyl alcohol, aryl iodides or aryl bromides, and arylboronic acids. The overall domino reaction yields were up to 70%.