期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2010, 期 2, 页码 292-299出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200900920
关键词
Alkaloids; Synthetic methods; Metalation; Cyclization; Reduction; Cycloacylation
资金
- National Key Project for Basic Research [2010CB126100]
- National Natural Science Foundation of China [20872072]
A concise, efficient and modular route involving Parham-type cycloacylation as the key step has been used to synthesize six enantiopure phenanthro-indolizidine alkaloids 1a-c. The preparation of enantiomerically pure tylophora alkaloids and their seco analogues on a large-scale is now feasible. The alcohol intermediates 8a-c, which are difficult to prepare by other synthetic methodologies, have been synthesized by a metallation-cyclization-reduction sequence in excellent yields.
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