期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2010, 期 16, 页码 3120-3128出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000185
关键词
Glycoclusters; Cysteine scaffold; Glycopeptides; Cell adhesion; Type 1 fimbriae
资金
- Christiana Albertina University of Kiel (CAU)
Clustermannosides of different valency were synthesised based on cysteine. By employing the orthogonally protected amino acid as scaffold molecule, a variety of structurally varied products can be obtained according to different synthetic routes. Testing of the prepared glycodusters as inhibitors of type 1 fimbriae mediated bacterial adhesion is reported, giving hints about the influence of sugar valency, sugar scaffolding, and the nature of the glycosidic aglycon in this testing system.
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