One-Pot Catalytic Glycosidation/Fmoc Removal - An Iterable Sequence for Straightforward Assembly of Oligosaccharides Related to HIV gp120

The removal of a transient Fmoc protecting group can be simply performed by the addition of excess Et3N just after the accomplishment of a Bi(OTf)(3)-promoted glycosidation reaction. The obtained oligosaccharide can be directly employed as a glycosyl acceptor for further elongation of the saccharide. The preparation of biologically important, linear and branched mannans incorporated into HIV gp120 demonstrates that the iteration of this one-pot sequence leads to a very straightforward oligosaccharide assembly.