期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2010, 期 13, 页码 2445-2448出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000199
关键词
Asymmetric catalysis; Chromium; Allenylmethanols; Dienes; Regioselectivity
资金
- Norman Hackerman Advanced Research
- Robert A Welch Foundation [A-1623]
[1-(Silylmethyl)allenyl]methanols 2 were efficiently synthesized from aldehydes and (4-bromobut-2-ynyl)trimethylsilane in the presence of a catalytic amount of CrCl2 and tridentate carbazole ligands The desired compounds were obtained with good yields (43-88%) and enantioselectivities (55-78% ee) Alcohols 2 may be treated with TBAF or 2 M HCI in the case of aliphatic substrates, to provide (1,3-butadien-2-yl)methanols 3 in 43-81% yields This method allows the synthesis of dienes 3 with no regioselectivity problems, and it tolerates a large number of functionalities
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