期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2010, 期 8, 页码 1461-1468出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200901350
关键词
Borylation; Biaryl peptides; Microwave chemistry; Cross-coupling; Solid-phase synthesis
资金
- Spanish Ministry of Education and Science (MEC)
- MEC of Spain [AGL2006-13564-C02-02/AGR]
Resin-bound phenylalanine boronates were prepared by solid-phase Miyaura borylation of 4-iodophenylalanine peptides. Subsequent arylation through a Suzuki-Miyaura cross-coupling was carried out using a variety of aryl halides under conventional heating and under microwave irradiation. Microwaves greatly enhanced the arylation, shortening the reaction time and providing the biaryl peptides in higher purities.
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