期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2010, 期 13, 页码 2429-2440出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200901338
关键词
Catalyst discovery; Dynamic combinatorial chemistry; Supramolecular catalysis; Noncovalent interactions; Molecular recognition
资金
- University of Padova [CPDA054893]
- European Research Council [FP7/2007-2013, 239898]
Catalyst development is a challenging task, caused by the subtle effects that determine whether a catalyst is efficient or not Success is enhanced by using methodology that relies to a smaller extent on rational design. Combinatorial high-throughput approaches allow for a systematic exploration of chemical space, but require an easy synthetic access to structurally diverse catalysts The use of dynamic or reversible chemistry for the construction of catalysts is an attractive option as it allows for self-assembly and self-selection processes. Synthesis is restricted to the building blocks after which diversity is simply generated upon mixing. Self-selection of the best catalyst by the target reaction relieves the burden of rational design Molecular systems exhibiting catalysis as an emerging property due to a cooperative interplay of the molecular components are envisioned for the future.
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