期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2009, 期 29, 页码 4911-4919出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200900211
关键词
Nitrogen heterocycles; Carbene equivalent; Cyclization; Ylides; Asymmetric synthesis
资金
- Engineering and Physical Sciences Research Council (EPSRC)
- Royal Society
- Royal Society of Chemistry (RSC)
- AstraZeneca
The development of new methods for the efficient synthesis of aziridines has been of considerable interest to researchers for more than 60 years, but no single method has yet emerged as uniformly applicable, especially for asymmetric synthesis of chiral aziridines. One method which has been intensely examined and expanded of late involves the nucleophilic addition to imines by anions bearing a-leaving groups; by analogy with the glycidate epoxide synthesis, these processes are often described as aza-Darzens reactions. This Microreview gives a summary of the area, with a focus on contemporary developments. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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